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KMID : 0978920230240010024
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Korean Journal of Clinical Geriatrics
2023 Volume.24 No. 1 p.24 ~ p.33
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Effect of Testosterone Supplementation on Cognition in Elderly Men: A Systematic Meta-Analysis
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Hong Seung-Wan
Cho Yoon-Jeong
Lee Jae-Hyuck
Suh Young-Sung
Kim Dae-Hyun
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Abstract
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Background: Cognitive function is an important issue in aging societies. Testosterone levels and cognitive function are known to be correlated; however, the clinical conclusions remain controversial. This study aimed to investigate whether testosterone supplementation improve cognitive function in adult men through a systematic meta-analysis.
Methods: A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The PubMed, Cochrane Library, and Embase databases were searched. Literature search, study identification, and data extraction were performed between December 2019 and March 2021.
Results: A total of 15 studies were included in the meta-analysis. The sample sizes of the selected studies varied from 11 to 493. There were no significant differences in cognitive speed (standardized mean difference [SMD]=?0.05; 95% confidence interval [CI], ?0.26 to 0.16), immediate verbal memory function (SMD=0.07; 95% CI, ?0.05 to 0.20), immediate visual memory function (SMD=?0.01; 95% CI, ?0.15 to 0.13), working memory function (SMD=?0.04; 95% CI, ?0.42 to 0.35), delayed memory function (SMD=?0.02; 95% CI, ?0.14 to 0.10), executive function (SMD=0.03; 95% CI, ?0.08 to 0.15), perception (SMD=?0.13; 95% CI, ?0.37 to 0.11), cognitive inhibition (SMD=?0.13; 95% CI, ?0.49 to 0.23), visual attention (SMD=?0.02; 95% CI, ?0.16 to 0.11), and cognitive status scores (SMD=?0.02; 95% CI, ?0.18 to 0.14).
Conclusion: The findings of this study indicate that there is a lack of evidence that testosterone administration has an effect on preventing cognitive decline. Therefore, testosterone use to prevent cognitive decline may not be recommended.
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KEYWORD
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Aging, Cognition, Hormone replacement therapy, Testosterone
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